TL-19-0B9A1B SYGNOMICS Report

SOC Drugs

# 1. Target: GSR

Drugs 1 Active Regulons 7 Regulon Activity 1 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

7 regulons containing the target(s), GSR are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

Glioblastoma Clinical Trials

Network Plots

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2. Target: VEGFA

Drugs 1 Active Regulons 19 Regulon Activity 0.826 Hallmarks 3 Mutated in patient No

Drugs

Model Evidence

19 regulons containing the target(s), VEGFA are overactive in this patient.

Hallmarks Enrichment

HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB

Literature Evidence

Glioblastoma Clinical Trials

Network Plots

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Drugs in GBM Trials

# 1. Target: RRM2

Drugs 1 Active Regulons 12 Regulon Activity 0.923 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

12 regulons containing the target(s), RRM2 are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

Glioblastoma Clinical Trials

Network Plots

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2. Target: GPD2,NDUFA13

Drugs 1 Active Regulons 15 Regulon Activity 1 Hallmarks 4 Mutated in patient No

Drugs

Model Evidence

15 regulons containing the target(s), GPD2,NDUFA13 are overactive in this patient.

Hallmarks Enrichment

HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_MYC_TARGETS_V1 HALLMARK_DNA_REPAIR HALLMARK_MTORC1_SIGNALING

Literature Evidence

Glioblastoma Clinical Trials

Network Plots

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3. Target: FNTA,FNTB

Drugs 1 Active Regulons 13 Regulon Activity 0.867 Hallmarks 1 Mutated in patient No

Drugs

Model Evidence

13 regulons containing the target(s), FNTA,FNTB are overactive in this patient.

Hallmarks Enrichment

HALLMARK_OXIDATIVE_PHOSPHORYLATION

Literature Evidence

Glioblastoma Clinical Trials

Network Plots

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FDA Approved Drugs

# 1. Target: APP

Drugs 8 Active Regulons 41 Regulon Activity 1 Hallmarks 2 Mutated in patient No

Drugs

Model Evidence

41 regulons containing the target(s), APP are overactive in this patient.

Hallmarks Enrichment

HALLMARK_ANGIOGENESIS HALLMARK_TNFA_SIGNALING_VIA_NFKB

Literature Evidence

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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2. Target: GPD2,NDUFA13

Drugs 1 Active Regulons 15 Regulon Activity 1 Hallmarks 4 Mutated in patient No

Drugs

Model Evidence

15 regulons containing the target(s), GPD2,NDUFA13 are overactive in this patient.

Hallmarks Enrichment

HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_MYC_TARGETS_V1 HALLMARK_DNA_REPAIR HALLMARK_MTORC1_SIGNALING

Literature Evidence

Glioblastoma Clinical Trials

Network Plots

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3. Target: GSR

Drugs 1 Active Regulons 7 Regulon Activity 1 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

7 regulons containing the target(s), GSR are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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4. Target: UGCG

Drugs 3 Active Regulons 51 Regulon Activity 1 Hallmarks 2 Mutated in patient No

Drugs

Model Evidence

51 regulons containing the target(s), UGCG are overactive in this patient.

Hallmarks Enrichment

HALLMARK_ANGIOGENESIS HALLMARK_TNFA_SIGNALING_VIA_NFKB

Literature Evidence

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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5. Target: ABL1

Drugs 5 Active Regulons 5 Regulon Activity 1 Hallmarks 2 Mutated in patient No

Drugs

Model Evidence

5 regulons containing the target(s), ABL1 are overactive in this patient.

Hallmarks Enrichment

HALLMARK_MITOTIC_SPINDLE HALLMARK_G2M_CHECKPOINT

Literature Evidence

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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6. Target: NDUFA13

Drugs 1 Active Regulons 5 Regulon Activity 1 Hallmarks 3 Mutated in patient No

Drugs

Model Evidence

5 regulons containing the target(s), NDUFA13 are overactive in this patient.

Hallmarks Enrichment

HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1

Literature Evidence

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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7. Target: TSG101

Drugs 1 Active Regulons 2 Regulon Activity 1 Hallmarks 3 Mutated in patient No

Drugs

Model Evidence

2 regulons containing the target(s), TSG101 are overactive in this patient.

Hallmarks Enrichment

HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1

Literature Evidence

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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8. Target: NCAM1

Drugs 2 Active Regulons 1 Regulon Activity 1 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

1 regulons containing the target(s), NCAM1 are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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9. Target: ABAT

Drugs 1 Active Regulons 17 Regulon Activity 1 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

17 regulons containing the target(s), ABAT are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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10. Target: TRPV4

Drugs 1 Active Regulons 1 Regulon Activity 1 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

1 regulons containing the target(s), TRPV4 are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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11. Target: RRM2

Drugs 2 Active Regulons 12 Regulon Activity 0.923 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

12 regulons containing the target(s), RRM2 are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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12. Target: SERPINE1

Drugs 1 Active Regulons 51 Regulon Activity 0.911 Hallmarks 8 Mutated in patient No

Drugs

Model Evidence

51 regulons containing the target(s), SERPINE1 are overactive in this patient.

Hallmarks Enrichment

HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_COMPLEMENT HALLMARK_TGF_BETA_SIGNALING HALLMARK_APOPTOSIS HALLMARK_PROTEIN_SECRETION HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_UV_RESPONSE_DN

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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13. Target: TNC

Drugs 4 Active Regulons 9 Regulon Activity 0.9 Hallmarks 1 Mutated in patient No

Drugs

Model Evidence

9 regulons containing the target(s), TNC are overactive in this patient.

Hallmarks Enrichment

HALLMARK_TNFA_SIGNALING_VIA_NFKB

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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14. Target: MAPK1,MAPK3

Drugs 3 Active Regulons 18 Regulon Activity 0.9 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

18 regulons containing the target(s), MAPK1,MAPK3 are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

Network Plots

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15. Target: FNTA,FNTB

Drugs 1 Active Regulons 13 Regulon Activity 0.867 Hallmarks 1 Mutated in patient No

Drugs

Model Evidence

13 regulons containing the target(s), FNTA,FNTB are overactive in this patient.

Hallmarks Enrichment

HALLMARK_OXIDATIVE_PHOSPHORYLATION

Literature Evidence

Glioblastoma Clinical Trials

Network Plots

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16. Target: ATP1A1

Drugs 4 Active Regulons 64 Regulon Activity 0.853 Hallmarks 4 Mutated in patient No

Drugs

Model Evidence

64 regulons containing the target(s), ATP1A1 are overactive in this patient.

Hallmarks Enrichment

HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_UV_RESPONSE_DN HALLMARK_TGF_BETA_SIGNALING

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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17. Target: JAK2

Drugs 6 Active Regulons 17 Regulon Activity 0.85 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

17 regulons containing the target(s), JAK2 are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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18. Target: HSPA8

Drugs 2 Active Regulons 25 Regulon Activity 0.833 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

25 regulons containing the target(s), HSPA8 are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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19. Target: SOD1

Drugs 1 Active Regulons 5 Regulon Activity 0.833 Hallmarks 2 Mutated in patient No

Drugs

Model Evidence

5 regulons containing the target(s), SOD1 are overactive in this patient.

Hallmarks Enrichment

HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_ADIPOGENESIS

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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20. Target: ACVR2B

Drugs 1 Active Regulons 5 Regulon Activity 0.833 Hallmarks 2 Mutated in patient No

Drugs

Model Evidence

5 regulons containing the target(s), ACVR2B are overactive in this patient.

Hallmarks Enrichment

HALLMARK_MITOTIC_SPINDLE HALLMARK_G2M_CHECKPOINT

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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21. Target: VEGFA

Drugs 3 Active Regulons 19 Regulon Activity 0.826 Hallmarks 3 Mutated in patient No

Drugs

Model Evidence

19 regulons containing the target(s), VEGFA are overactive in this patient.

Hallmarks Enrichment

HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB

Literature Evidence

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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22. Target: EEF2

Drugs 2 Active Regulons 9 Regulon Activity 0.818 Hallmarks 0 Mutated in patient No

Drugs

Model Evidence

9 regulons containing the target(s), EEF2 are overactive in this patient.

Hallmarks Enrichment

None

Literature Evidence

No additional evidence was found

Glioblastoma Clinical Trials

No glioblastoma clinical trials were found for these drugs.

Network Plots

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